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Health & Medical

Oil-Soluble vs. Water-Soluble


Medications in general can be administered in multiple ways.

So are the ways, and time it takes, for our bodies process and metabolize them in order for us to receive their benefits.

This is largely due to the first pass effect, which is a chemical and physiological reaction that forces the concentration of medication to be reduced before it’s fully circulated. In other words, the amount your body actually gets is less than what you originally took.

CBD functions in similar fashion where its bioavailability is concerned and the differences in solubility are the key factors.


Certain administrations such as topicals (lotions and creams) can become quickly absorbed through the skin, and other oil-soluble CBD products like pills and even vaping can register many benefits. However, they cannot always effectively maintain their full bioavailability. This means that to get the full effect of their benefits, you may have to utilize this type of solution more often.


Water-soluble formats make it much easier for the body to absorb and process the compound. Much like soaking greasy dishes with soap in the sink, the components become essentially emulsified and thus quicker to digest. The other main benefit of water-soluble CBD is that you can use it in virtually anything you eat or drink. When you consume it orally, the process remains stable and their bioavailability levels do not decrease.

Whether oil-soluble or water-soluble is better for you depends on your individual needs and dosage recommendations. Either format is beneficial, though the onset of their positive effects is generally felt quicker with the water-soluble format.

For more questions on whether oil or water-soluble CBD might be right for you, and to try them for yourself, visit Your CBD Store – Sauk Valley’s first and only dedicated CBD store.

Your CBD Store of Sterling


2900 E Lincolnway #20D

Sterling, IL 61081