Kevin Youkilis hit a grand slam, Paul Konerko homered and Dewayne Wise had four hits Tuesday night as the White Sox rallied for the second straight game to beat the New York Yankees 7-3 in Chicago.

Chicago, which fell behind 3-0 in Monday night's opener before winning 9-6, trailed 2-0 after one inning Tuesday in the matchup of division leaders.

Wise, designated for assignment by the Yankees in July, had four singles from the leadoff spot and has played well while filling in for the injured Alejandro De Aza.

It was Youkilis' second grand slam this season at U.S. Cellular Field. He also cleared the bases in April for Boston against the White Sox and Phil Humber.

Since joining the White Sox in a June trade with the Red Sox, Youkilis has hit 11 of his 15 homers.

Brewers 5, Cubs 2: Marco Estrada allowed two hits in six solid innings to win for the first time in almost a year, leading the Brewers over the Cubs in Milwaukee.

Estrada (1-5) started for the 16th time this season and made 14 relief appearances over this season and last since his win at Pittsburgh on Aug. 23, 2011.

The Brewers right-hander gave up Alfonso Soriano's double leading off the second and rookie starter Chris Rusin's first major league hit, a one-out triple in the third. Estrada worked retired David DeJesus on a comebacker and then Josh Vitters took a called third strike to end the inning.

Estrada retired 18 of 21 batters before turning over a 1-0 lead to Kameron Loe to start the seventh.